nybanner

        Products

        API-Drug Peptide Pepstatin/ PepstatinA Inhibition of pepsin, cathepsin D and HIV protease

        Short Description:

        Pepstatin A is a pentapeptide inhibitor of aspartic protease derived from bacteria. Pepstatin A is a potent inhibitor of aspartic protease, and can inhibit the replication of HIV. Pepstatin A is also an inhibitor of cathepsins D and cathepsins e. Pepstatin A inhibits autophagy by inhibiting lysosomal protease.


        Product Detail

        Product Tags

        About This Item

        Pepstatin is a pentapeptide, a naturally occurring aspartyl protease inhibitor, which can inhibit aspartic protease and acid protease of various microorganisms. Pepstatin is mainly secreted by Streptomyces species and produced by Streptomyces. It can inhibit pepsin, pepsin D and angiotensin-releasing enzyme, and has therapeutic effects on gastric ulcer, renal hypertension, arthritis, carrageenan edema and other diseases.

        Pepstatin is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. This natural pentapeptide isolated from actinomycetes was for many years the classic renin inhibitor in vitro.Pepstatin is not specific for renin and is poorly soluble in water. Structural derivatives of pepstatin increased its solubility and specificity for renin by several orders of magnitude.Pepstatin contains the unusual γ amino acid statin that may substitute for the two amino acids at the scissile bond of the?protein substrate and block substrate cleavage because of the structural analogy to a transition state of the peptide bond hydrolysis by aspartyl proteases.

        Product Dispaly

        IMG_20200609_154048
        IMG_20200609_155449
        IMG_20200609_161417

        Why Choose Us

        When protein is extracted from broken cells, proteases can be released, which need to be rapidly inhibited to keep protein from being degraded. In the process of protein extraction, protease inhibitors need to be added to prevent proteolysis. Protease inhibitor broadly refers to a substance that binds to some groups on the active center of protease molecules, so that the protease activity decreases or even disappears, but does not denature the enzyme protein. The sensitivity of various proteases to different protein is different, so it is necessary to adjust the concentration of various proteases. Because the solubility of protease inhibitor in liquid is extremely low, it should be paid special attention to that protease inhibitor should be fully mixed in the buffer to reduce the precipitation of protease inhibitor. Pepstantin A can inhibit acid proteases such as pepsin, angiotensin, collagenase, cathepsin D and chymosin.

        API-Drug Peptid1

        Pepstatin A is an inhibitor of cathepsin d and e. After HEK293 cells were treated with different concentrations of pepstatin A for 24 hours, the expression of LC3Ⅱ and p62 was detected. The results showed that pepstatin A could significantly enhance the expression of LC3Ⅱ and P62 (P < 0.05) in a dose-dependent manner. 20μ g/ml pepstatin A was used to treat HEK293 at different time intervals, and the effects of different time intervals on the expression of LC3II and p62 were observed. The results showed that pepstatin A could up-regulate the expression of LC3II and p62 in a time-dependent manner.

        We are a polypeptide manufacturer in China, with several years of mature experience in polypeptide production. Hangzhou Taijia Biotech Co., Ltd. is a professional polypeptide raw material manufacturer, which can provide tens of thousands of polypeptide raw materials and can also be customized according to needs. The quality of polypeptide products is excellent, and the purity can reach 98%, which has been recognized by users all over the world.Welcome to consult us.


      1. Previous:
      2. Next:

      3. 主站蜘蛛池模板: 国产精品无码a∨精品| 日韩丰满少妇无码内射| 台湾佬在线观看| 欧美日韩一区二区不卡三区| 女人张开腿让男人插| 久久天天躁狠狠躁夜夜2020一| 欧美黑人xxxx| 午夜天堂一区人妻| 久久中文字幕无码专区| 美女被免费视频网站a| 国产精品一区二区久久乐下载 | 五月婷婷丁香在线| 爱豆在线观看网址91|免费| 国产h肉在线视频免费观看| 2020国产精品自拍| 大学生男男澡堂69gaysex| 中文字幕不卡在线高清| 日韩黄a级成人毛片| 亚洲欧美校园春色| 91福利视频导航| 成人毛片18女人毛片免费| 亚欧免费视频一区二区三区| 海角社区hjb09| 又黄又爽又色的黄裸乳视频| 黄床大片免费30分钟国产精品| 国产超清在线观看| 久久精品国产99精品最新| 欧美黑人玩白人巨大极品 | 《波多野结衣系列mkmp-305》 | 91传媒蜜桃香蕉在线观看| 少妇大叫太大太爽受不了| 久久久精品久久久久特色影视 | 亚洲精品无码专区在线| 精品久久国产视频| 国产丰满乱子伦无码专区| 人人洗澡人人洗澡人人| 国产美女在线观看| av片在线观看永久免费| 小说区综合区首页| 中文字幕日韩精品麻豆系列| 日韩aⅴ人妻无码一区二区|